In a recent study published in eLife, we show that metacognition (the ability to consciously judge one’s performance) can be enhanced using a drug called propranolol. Propranolol blocks beta-adrenoceptors and thus impairs the effect of noradrenaline. Using a double-blind, placebo controlled drug study, we show that propranolol specifically enhances metacognition, but not perceptual decision making performance. A dopamine blockade (using amisulpride) did not affect either process.
Our paper also received some media coverage: The New Scientist just published a nice article about the study. Please note that the title of the article is misleading and was not approved by us. This study investigates the effect of drugs on metacognition and has nothing to do with OCD or OCD treatment.
Hauser TU*, Allen M*, Purg N, Moutoussis M, Rees G & Dolan R (2017). Noradrenaline blockade specifically enhances metacognitive performance. eLife 6: e24901