Our new paper in Trends in Neurosciences, we explain how computational psychiatry tries to understand the mechanisms in psychiatric disorders like attention deficit hyperactivity disorder (ADHD). We demonstrate how important it is to have an understanding of several levels of description (Marr’s levels of analysis), and to combine these levels to develop biologically driven, mechanistic new hypotheses about pathomechanisms. In this paper we further suggest that ADHD is mainly a disorder of aberrant neural gain modulation and we show how converging evidence on different levels of description support our notion.
Hauser TU, Fiore V, Moutoussis M & Dolan RJ (2016). Computational Psychiatry of ADHD: Neural Gain Impairments across Marrian Levels of Analysis. Trends Neurosci.